Covaryl - Molsidomine
IDENTIFICATION OF MEDICINE
FORMS AND PRESENTATIONS
Tablet. Box of 30.
COMPOSITION
2,4 mg molsidomine
for a tablet.
Excipients: lactose monohydrate, crospovidone, magnesium stearate, macrogol 6000.
CLASS PHAMACOTHERAPEUTIQUE
OTHER VASODILATOR CARDIOLOGY
INDICATIONS
This drug is an anti-anginal.
This drug is recommended in the treatment of severe angina pectoris.
CORVARYL is not a medicine for the treatment of angina pectoris.
DOSAGE AND ADMINISTRATION
DOSAGE
The recommended dosage is 1 tablet 3 times a day in some cases of angina pectoris, the dosage may be increased to 4 tablets per day, or 16 mg of molsidomine day.
The daily dose is to be divided and adjusted for each case.
ADMINISTRATION
Orally.
CONTRAINDICATIONS
• Significant Hypotension and shock.
• Association with VIAGRA (sildenafil):
- If traitmenet by molsidomine, sildenafil must not être.utilisé ASPD,
- In case of treatment with sildenafil, molsidomine should not be used.
• This medicine is generally not recommended during lactation.
WARNINGS and PRECAUTIONS
WARNINGS
- The combination of molsidomine on VIAGRA (sildenafil) can cause large and sudden drop in blood pressure can cause faintness, fainting, or a heart attack.
- Due to the presence of lactose, this drug should not be used in case of galactosemia, malabsorption of glucose and galactose or lactase deficiency
PRECAUTIONS
- A slight hypotension is common in molsidomine. This medication should be used with caution in patients with low blood pressure, as well as in the elderly, in patients with hypovolemia, and in patients previously treated
with a substance vasodiiatatrice
- In cases of liver failure, it is recommended to increase the dosage gradually.
- It is not logical to associate with molsidomine delay nitro derivatives, insofar as their mechanism of action is similar.
LIST OF EXCIPIENTS WHICH KNOWLEDGE IS REQUIRED FOR SAFE USE SOME PATIENTS
Lactose.
INTERACTIONS
PREGNANCY and BREAST-FEEDING
It is preferable not to use this medicine during pregnancy.
Breastfeeding is not recommended during treatment.
ADVERSE REACTIONS
- Slight headache and hypotension in early treatment. These effects resolve spontaneously within a few days;
- Exceptionally: orthostatic hypotension, digestive disorders, itching.
CORVARYL
Antianginal
In which case the drug CORVARYL is prescribed?
This medicine vasodilator , which has multiple properties, belongs to the family of antianginal .
It is used in the preventive treatment of of crises angina .
You can look (s) Item (s) to:
Angina (angina)
Drug presentations CORVARYL
CORVARYL 2 mg tablets scored (white) box of 30
Prescription (List I) - Refundable 65% - Price: € 4.80.
CORVARYL 2 mg tablets scored (white) box 90
Prescription (List I) - Refundable 65% - Price: € 12.06.
CORVARYL 4 mg tablets scored (white) box of 30
Prescription (List I) - Refundable 65% - Price: € 7.47.
Composition of the drug CORVARYL
p cp p cp
Molsidomine 2 mg 4 mg
Active substance: Molsidomine
Excipients: crospovidone, lactose monohydrate, macrogol 6000, magnesium stearate
Cons-indications of drug CORVARYL
This medication should not be used in combination with sildenafil (Viagra).
Attention
Precautions are necessary in people suffering from hypotension and blood in the elderly, especially if they are hypotensive.
CORVARYL drug interactions with other substances
This medicine vasodilator should not be associated with VIAGRA downside risk of serious tension.
Fertility, pregnancy and lactation
The effect of this medicine during pregnancy or lactation is not well known: Only your doctor can assess the possible risk of its use in your case.
Instructions for use and dosage of the drug CORVARYL
The tablets should be taken with a glass of water at mealtimes.
Usual dose:
It varies depending on the severity of the disease: 1/2 2 mg tablet 3 times a day, up to 4 mg 1 tablet 4 times a day.
Advice
In the elderly, especially during periods of high heat, it is helpful to drink enough to avoid a drop in blood pressure .
Possible side effects of the drug CORVARYL
Headache, common in early treatment, limited by a gradual increase in dosage .
Drop in blood pressure , usually moderate.
Exceptionally: digestive disorders , dizziness, itching.
You felt an adverse effect may be due to this medicine, you can declare by downloading the form.
CORVARYL: indications
- Preventive treatment of angina attack in all its forms.
- CORVARYL tablets are not suitable for the treatment of angina pectoris.
CORVARYL: conditions for which it may be prescribed
• Angina in all its forms
Therapeutic class Cardiology and Angiology
Active ingredients Molsidomine
Excipients Lactose, crospovidone (E1202), Magnesium stearate (E572), macrogol
Status Medicinal product subject to medical prescription
Selling price inclusive € 12.06
Tx repayment SS 65%
Laboratory Sanofi-Aventis France
Presentation Precautions Pregnancy and lactation Adverse
CORVARYL: its dosage
- Angina of effort (usual dose): 1/2 to 1 tablet 3 times a day, usually the morning meal, lunch and evening (3-6 mg of molsidomine).
- Angor rest angina and severe stress: 1 tablet 4 times a day (8 mg molsidomine).
The choice of dose and administration schedule can be adjusted exactly to the treatment of angina severity and pace of patient activity. In case of spontaneous angina, 4th will be taken preferably at bedtime.
CORVARYL: its appearance and shape
Scored tablet white.
CORVARYL: presentation
CORVARYL: how it works
OTHER VASODILATOR CARDIOLOGY.
ATC Code: C01DX12 (C: Cardiovascular system).
Molsidomine is the first representative of a new anti-anginal family, sydnonimines.
- In animals:
. Molsidomine increases venous capacitance sustainable manner thereby inducing a reduction in venous return. Systemic blood pressure tends to be lowered and attached to this phenomenon reducing venous return
causes a decrease in the left ventricular wall stress and therefore the myocardial oxygen consumption.
. Furthermore, it causes a redistribution of the blood of the epicardium to endocardium, and particularly in ischemic areas.
. It induces relaxation of vascular smooth fiber, and thus causes dilation of large epicardial trunks.
. At therapeutic doses molsidomine does not affect the inotropic and increases only little or no heart rate despite the slight decrease in peripheral resistance.
. Molsidomine does not act on the calcium conductance and has no effect on the autonomic nervous system.
. Molsidomine exerts animal antithrombotic properties coronal region and is able to limit the size of experimental infarction.
- In vitro, the action of molsidomine is at two levels:
. Smooth muscle:
. relaxation of vascular smooth muscle fiber;
. without metabolic transformation involving cysteine, which does not exhibit the phenomenon of tachyphylaxis or therapeutic escape;
. accompanied by increased levels of cyclic GMP.
. Brochure:
inhibition of early phases of platelet activation with a consequent decrease in the secretion (or synthesis) of the major pro-aggregating agents and / or platelet vasoconstrictor (serotonin, PAF acether, thromboxane)
without modification of the endothelial prostacyclin secretion , vasodilatory and anti-platelet.
- These actions are similar to those described for the NO radical, one of the main relaxing factors released by the vascular endothelium (EDRF). They are probably due to the direct release of this radical in the
biotransformations undergone by molsidomine.
- These pharmacological properties are found in humans. They explain that molsidomine prevents manifestations of exertional angina or rest.
- Molsidomine is an NO donor (nitrogen monoxide). The nitric oxide stimulates the formation of cGMP, resulting in a decrease in intracellular calcium levels and vascular relaxation.
GLOSSARY
angina
Oppressive pain due to partial obstruction of the coronary arteries that supply the heart muscle. It can occur in the chest, arm or jaw.
Synonym: angina.
dosage
Quantity and distribution of the dose of a medicament according to the age, weight and general condition of the patient.
preventive treatment
Treatment to prevent disease (synonym: prophylaxis), or limit the frequency of seizures or pushed into a chronic disease.
digestive disorders
Set of symptoms of increased irritation or malfunction of the digestive tract. One or more conditions may be present: nausea, vomiting, flatulence, abdominal pain, heartburn, bloating, flatulence, diarrhea or
constipation burns, etc.. Antibiotics may promote candidiasis often cause digestive disorders.
vasodilator
Drug capable of dilating blood vessels (artery, vein), as opposed to vasoconstrictor.
dizziness
Symptom may designate a sense of loss of balance (common sense) or, more strictly, a spinning sensation of oneself or the environment (medical direction).
Indications
- Preventive treatment of angina attack in all its forms.
- CORVARYL tablets are not suitable for the treatment of angina pectoris.
CORVARYL dose 2 mg scored tablet Box of 30
- Angina of effort (usual dose): 1/2 to 1 tablet 3 times a day, usually the morning meal, lunch and evening (3-6 mg of molsidomine).
- Angor rest angina and severe stress: 1 tablet 4 times a day (8 mg molsidomine).
The choice of dose and administration schedule can be adjusted exactly to the treatment of angina severity and pace of patient activity. In case of spontaneous angina, 4th will be taken preferably at bedtime.
Indications against
CONTRAINDICATED:
This drug should not be prescribed in the following cases:
- Marked hypotension and shock.
- Association to sildenafil (see interactions and warnings):
. in any patient treated with molsidomine should not prescribe sildenafil as the patient is under the action of molsidomine.
. in case of treatment with sildenafil, molsidomine is cons-indicated.
In patients without coronary history with a first episode of angina at the waning of sexual activity, should be sought by questioning the possible taking sildenafil (most often in the hour before sexual activity)
and if such is the case refrain from treatment with molsidomine.
In general, according to available data, the time limit before administering molsidomine a patient exposed to sildenafil is not precisely known but can be estimated at a minimum of 24 hours.
- Due to the presence of lactose, this medicine is against-indicated in cases of congenital galactosemia, malabsorption of glucose and galactose or lactase deficiency.
RECOMMENDED:
This medicine is generally not recommended during breast-feeding: breastfeeding is not recommended due to the lack of data transfer in the milk.
Adverse CORVARYL
- The usually mild headache and a slight decrease in blood pressure may occur early in treatment. Headaches usually resolve spontaneously within a few days. These effects may be increased by concomitant use of other vasodilators.
A gradual dose allows to reduce the frequency.
- Exceptionally were reported orthostatic hypotension, digestive disorders, dizziness, or itching.
Use
Therapeutic indications
- Severe angina, rebellious to the usual doses of molsidomine.
- CORVARYL tablets are not suitable for the treatment of angina pectoris.
Dosage and administration
Severe angina: 1 tablet 3 times a day (12 mg of molsidomine).
4th tablet may be necessary in some rebel unstable angina (16 mg molsidomine).
Effective dose should be achieved gradually due to the risk of headache in some subjects.
The daily dose should be adjusted and allocated for the observed effectiveness and the rate of activity of the patient.
Duration and any special storage
Shelf life: 3 years.
Special precautions for storage:
Store at a temperature below 25 ° C and protected from light.
Incompatibilities
Not applicable.
Safety Data
Not applicable.
Precautions
Indication against
CONTRAINDICATED:
This drug should not be prescribed in the following cases:
- Marked hypotension and shock.
- Association to sildenafil (see interactions and warnings):
. in any patient treated with molsidomine should not prescribe sildenafil as the patient is under the action of molsidomine.
. in case of treatment with sildenafil, molsidomine is cons-indicated.
In patients without coronary history with a first episode of angina at the waning of sexual activity, should be sought by questioning the possible taking sildenafil (most often in the hour before sexual activity) and if such is
the case refrain from treatment with molsidomine.
In general, according to available data, the time limit before administering molsidomine a patient exposed to sildenafil is not precisely known but can be estimated at a minimum of 24 hours.
- Due to the presence of lactose, this medicine is against-indicated in cases of congenital galactosemia, malabsorption of glucose and galactose or lactase deficiency.
RECOMMENDED:
This medicine is generally not recommended during breast-feeding: breastfeeding is not recommended due to the lack of data transfer in the milk.
Pregnancy and Breastfeeding
Pregnancy:
Studies in animals have not revealed teratogenic. In the absence of teratogenic effects in animals, a teratogen in humans is not expected. Indeed, to date, the substances responsible for malformations in humans have proven
teratogenic in animals in studies conducted in two species well.
Clinically, there is currently no adequate data to evaluate a possible harmful effect of molsidomine when administered during pregnancy.
Consequently, as a precautionary measure, it is preferable not to use molsidomine during pregnancy.
Breastfeeding:
Breastfeeding is not recommended due to the lack of data transfer in the milk.
Caution
WARNINGS:
- CORVARYL tablets are not suitable for the treatment of angina pectoris.
- Association of molsidomine to sildenafil:
the combination of molsidomine to sildenafil may cause large and sudden drop in blood pressure may be at the origin of faintness, syncope or acute coronary event (see interactions and cons- directions).
- Due to the presence of lactose, this medicine is against-indicated in cases of congenital galactosemia, malabsorption of glucose and galactose or lactase deficiency.
PRECAUTIONS:
- A slight drop in blood pressure is usual under molsidomine. Some caution is necessary in hypotensive patients, particularly in the elderly and / or hypovolemic (acute or chronic salt depletion) and in patients previously
treated with a vasodilator substance.
- A gradual dose is recommended in patients with hepatic insufficiency.
- Devoid of any myocardial depressant effect, molsidomine may be associated with beta-blockers. It has no effect on conduction of the fabric.
- The substitution of nitrates delay is more logical than the association, due to joint action on the preload.
- It is not logical to combine with nitrates molsidomine extended insofar as their mechanism of action is similar action derivatives.
- Pregnancy: Animal studies have not demonstrated a teratogenic effect. In the absence of teratogenic effects in animals, a teratogen in humans is not expected. Indeed, to date, the substances responsible for malformations in
humans have proven teratogenic in animals in studies conducted in two species well. Clinically, there is currently no adequate data to evaluate a possible harmful effect of molsidomine when administered during pregnancy.
Consequently, as a precautionary measure, it is preferable not to use molsidomine during pregnancy.
Interactions with other drugs
Contraindicated:
Sildenafil:
Risk of significant hypotension (synergistic effect) can worsen the condition and cause of myocardial ischemia including an acute coronary event.
Adverse effects
- The usually mild headache and a slight decrease in blood pressure may occur early in treatment. Headaches usually resolve spontaneously within a few days. These effects may be increased by concomitant use of other vasodilators.
A gradual dose allows to reduce the frequency.
- Exceptionally were reported orthostatic hypotension, digestive disorders, dizziness, or itching.
Overdose
Significant hypotension can be controlled by placing the patient supine, head sloping, with elevation of the lower limbs and the need for an intravenous infusion of normal saline or any other means of volume expansion.
Composition
Excipient
Lactose
Crospovidone (E1202)
Magnesium stearate (E572)
Macrogol
IDENTIFICATION OF MEDICINE
FORMS AND PRESENTATIONS
Tablet. Box of 30.
COMPOSITION
2,4 mg molsidomine
for a tablet.
Excipients: lactose monohydrate, crospovidone, magnesium stearate, macrogol 6000.
CLASS PHAMACOTHERAPEUTIQUE
OTHER VASODILATOR CARDIOLOGY
INDICATIONS
This drug is an anti-anginal.
This drug is recommended in the treatment of severe angina pectoris.
CORVARYL is not a medicine for the treatment of angina pectoris.
DOSAGE AND ADMINISTRATION
DOSAGE
The recommended dosage is 1 tablet 3 times a day in some cases of angina pectoris, the dosage may be increased to 4 tablets per day, or 16 mg of molsidomine day.
The daily dose is to be divided and adjusted for each case.
ADMINISTRATION
Orally.
CONTRAINDICATIONS
• Significant Hypotension and shock.
• Association with VIAGRA (sildenafil):
- If traitmenet by molsidomine, sildenafil must not être.utilisé ASPD,
- In case of treatment with sildenafil, molsidomine should not be used.
• This medicine is generally not recommended during lactation.
WARNINGS and PRECAUTIONS
WARNINGS
- The combination of molsidomine on VIAGRA (sildenafil) can cause large and sudden drop in blood pressure can cause faintness, fainting, or a heart attack.
- Due to the presence of lactose, this drug should not be used in case of galactosemia, malabsorption of glucose and galactose or lactase deficiency
PRECAUTIONS
- A slight hypotension is common in molsidomine. This medication should be used with caution in patients with low blood pressure, as well as in the elderly, in patients with hypovolemia, and in patients previously treated
with a substance vasodiiatatrice
- In cases of liver failure, it is recommended to increase the dosage gradually.
- It is not logical to associate with molsidomine delay nitro derivatives, insofar as their mechanism of action is similar.
LIST OF EXCIPIENTS WHICH KNOWLEDGE IS REQUIRED FOR SAFE USE SOME PATIENTS
Lactose.
INTERACTIONS
PREGNANCY and BREAST-FEEDING
It is preferable not to use this medicine during pregnancy.
Breastfeeding is not recommended during treatment.
ADVERSE REACTIONS
- Slight headache and hypotension in early treatment. These effects resolve spontaneously within a few days;
- Exceptionally: orthostatic hypotension, digestive disorders, itching.
CORVARYL
Antianginal
In which case the drug CORVARYL is prescribed?
This medicine vasodilator , which has multiple properties, belongs to the family of antianginal .
It is used in the preventive treatment of of crises angina .
You can look (s) Item (s) to:
Angina (angina)
Drug presentations CORVARYL
CORVARYL 2 mg tablets scored (white) box of 30
Prescription (List I) - Refundable 65% - Price: € 4.80.
CORVARYL 2 mg tablets scored (white) box 90
Prescription (List I) - Refundable 65% - Price: € 12.06.
CORVARYL 4 mg tablets scored (white) box of 30
Prescription (List I) - Refundable 65% - Price: € 7.47.
Composition of the drug CORVARYL
p cp p cp
Molsidomine 2 mg 4 mg
Active substance: Molsidomine
Excipients: crospovidone, lactose monohydrate, macrogol 6000, magnesium stearate
Cons-indications of drug CORVARYL
This medication should not be used in combination with sildenafil (Viagra).
Attention
Precautions are necessary in people suffering from hypotension and blood in the elderly, especially if they are hypotensive.
CORVARYL drug interactions with other substances
This medicine vasodilator should not be associated with VIAGRA downside risk of serious tension.
Fertility, pregnancy and lactation
The effect of this medicine during pregnancy or lactation is not well known: Only your doctor can assess the possible risk of its use in your case.
Instructions for use and dosage of the drug CORVARYL
The tablets should be taken with a glass of water at mealtimes.
Usual dose:
It varies depending on the severity of the disease: 1/2 2 mg tablet 3 times a day, up to 4 mg 1 tablet 4 times a day.
Advice
In the elderly, especially during periods of high heat, it is helpful to drink enough to avoid a drop in blood pressure .
Possible side effects of the drug CORVARYL
Headache, common in early treatment, limited by a gradual increase in dosage .
Drop in blood pressure , usually moderate.
Exceptionally: digestive disorders , dizziness, itching.
You felt an adverse effect may be due to this medicine, you can declare by downloading the form.
CORVARYL: indications
- Preventive treatment of angina attack in all its forms.
- CORVARYL tablets are not suitable for the treatment of angina pectoris.
CORVARYL: conditions for which it may be prescribed
• Angina in all its forms
Therapeutic class Cardiology and Angiology
Active ingredients Molsidomine
Excipients Lactose, crospovidone (E1202), Magnesium stearate (E572), macrogol
Status Medicinal product subject to medical prescription
Selling price inclusive € 12.06
Tx repayment SS 65%
Laboratory Sanofi-Aventis France
Presentation Precautions Pregnancy and lactation Adverse
CORVARYL: its dosage
- Angina of effort (usual dose): 1/2 to 1 tablet 3 times a day, usually the morning meal, lunch and evening (3-6 mg of molsidomine).
- Angor rest angina and severe stress: 1 tablet 4 times a day (8 mg molsidomine).
The choice of dose and administration schedule can be adjusted exactly to the treatment of angina severity and pace of patient activity. In case of spontaneous angina, 4th will be taken preferably at bedtime.
CORVARYL: its appearance and shape
Scored tablet white.
CORVARYL: presentation
CORVARYL: how it works
OTHER VASODILATOR CARDIOLOGY.
ATC Code: C01DX12 (C: Cardiovascular system).
Molsidomine is the first representative of a new anti-anginal family, sydnonimines.
- In animals:
. Molsidomine increases venous capacitance sustainable manner thereby inducing a reduction in venous return. Systemic blood pressure tends to be lowered and attached to this phenomenon reducing venous return
causes a decrease in the left ventricular wall stress and therefore the myocardial oxygen consumption.
. Furthermore, it causes a redistribution of the blood of the epicardium to endocardium, and particularly in ischemic areas.
. It induces relaxation of vascular smooth fiber, and thus causes dilation of large epicardial trunks.
. At therapeutic doses molsidomine does not affect the inotropic and increases only little or no heart rate despite the slight decrease in peripheral resistance.
. Molsidomine does not act on the calcium conductance and has no effect on the autonomic nervous system.
. Molsidomine exerts animal antithrombotic properties coronal region and is able to limit the size of experimental infarction.
- In vitro, the action of molsidomine is at two levels:
. Smooth muscle:
. relaxation of vascular smooth muscle fiber;
. without metabolic transformation involving cysteine, which does not exhibit the phenomenon of tachyphylaxis or therapeutic escape;
. accompanied by increased levels of cyclic GMP.
. Brochure:
inhibition of early phases of platelet activation with a consequent decrease in the secretion (or synthesis) of the major pro-aggregating agents and / or platelet vasoconstrictor (serotonin, PAF acether, thromboxane)
without modification of the endothelial prostacyclin secretion , vasodilatory and anti-platelet.
- These actions are similar to those described for the NO radical, one of the main relaxing factors released by the vascular endothelium (EDRF). They are probably due to the direct release of this radical in the
biotransformations undergone by molsidomine.
- These pharmacological properties are found in humans. They explain that molsidomine prevents manifestations of exertional angina or rest.
- Molsidomine is an NO donor (nitrogen monoxide). The nitric oxide stimulates the formation of cGMP, resulting in a decrease in intracellular calcium levels and vascular relaxation.
GLOSSARY
angina
Oppressive pain due to partial obstruction of the coronary arteries that supply the heart muscle. It can occur in the chest, arm or jaw.
Synonym: angina.
dosage
Quantity and distribution of the dose of a medicament according to the age, weight and general condition of the patient.
preventive treatment
Treatment to prevent disease (synonym: prophylaxis), or limit the frequency of seizures or pushed into a chronic disease.
digestive disorders
Set of symptoms of increased irritation or malfunction of the digestive tract. One or more conditions may be present: nausea, vomiting, flatulence, abdominal pain, heartburn, bloating, flatulence, diarrhea or
constipation burns, etc.. Antibiotics may promote candidiasis often cause digestive disorders.
vasodilator
Drug capable of dilating blood vessels (artery, vein), as opposed to vasoconstrictor.
dizziness
Symptom may designate a sense of loss of balance (common sense) or, more strictly, a spinning sensation of oneself or the environment (medical direction).
Indications
- Preventive treatment of angina attack in all its forms.
- CORVARYL tablets are not suitable for the treatment of angina pectoris.
CORVARYL dose 2 mg scored tablet Box of 30
- Angina of effort (usual dose): 1/2 to 1 tablet 3 times a day, usually the morning meal, lunch and evening (3-6 mg of molsidomine).
- Angor rest angina and severe stress: 1 tablet 4 times a day (8 mg molsidomine).
The choice of dose and administration schedule can be adjusted exactly to the treatment of angina severity and pace of patient activity. In case of spontaneous angina, 4th will be taken preferably at bedtime.
Indications against
CONTRAINDICATED:
This drug should not be prescribed in the following cases:
- Marked hypotension and shock.
- Association to sildenafil (see interactions and warnings):
. in any patient treated with molsidomine should not prescribe sildenafil as the patient is under the action of molsidomine.
. in case of treatment with sildenafil, molsidomine is cons-indicated.
In patients without coronary history with a first episode of angina at the waning of sexual activity, should be sought by questioning the possible taking sildenafil (most often in the hour before sexual activity)
and if such is the case refrain from treatment with molsidomine.
In general, according to available data, the time limit before administering molsidomine a patient exposed to sildenafil is not precisely known but can be estimated at a minimum of 24 hours.
- Due to the presence of lactose, this medicine is against-indicated in cases of congenital galactosemia, malabsorption of glucose and galactose or lactase deficiency.
RECOMMENDED:
This medicine is generally not recommended during breast-feeding: breastfeeding is not recommended due to the lack of data transfer in the milk.
Adverse CORVARYL
- The usually mild headache and a slight decrease in blood pressure may occur early in treatment. Headaches usually resolve spontaneously within a few days. These effects may be increased by concomitant use of other vasodilators.
A gradual dose allows to reduce the frequency.
- Exceptionally were reported orthostatic hypotension, digestive disorders, dizziness, or itching.
Use
Therapeutic indications
- Severe angina, rebellious to the usual doses of molsidomine.
- CORVARYL tablets are not suitable for the treatment of angina pectoris.
Dosage and administration
Severe angina: 1 tablet 3 times a day (12 mg of molsidomine).
4th tablet may be necessary in some rebel unstable angina (16 mg molsidomine).
Effective dose should be achieved gradually due to the risk of headache in some subjects.
The daily dose should be adjusted and allocated for the observed effectiveness and the rate of activity of the patient.
Duration and any special storage
Shelf life: 3 years.
Special precautions for storage:
Store at a temperature below 25 ° C and protected from light.
Incompatibilities
Not applicable.
Safety Data
Not applicable.
Precautions
Indication against
CONTRAINDICATED:
This drug should not be prescribed in the following cases:
- Marked hypotension and shock.
- Association to sildenafil (see interactions and warnings):
. in any patient treated with molsidomine should not prescribe sildenafil as the patient is under the action of molsidomine.
. in case of treatment with sildenafil, molsidomine is cons-indicated.
In patients without coronary history with a first episode of angina at the waning of sexual activity, should be sought by questioning the possible taking sildenafil (most often in the hour before sexual activity) and if such is
the case refrain from treatment with molsidomine.
In general, according to available data, the time limit before administering molsidomine a patient exposed to sildenafil is not precisely known but can be estimated at a minimum of 24 hours.
- Due to the presence of lactose, this medicine is against-indicated in cases of congenital galactosemia, malabsorption of glucose and galactose or lactase deficiency.
RECOMMENDED:
This medicine is generally not recommended during breast-feeding: breastfeeding is not recommended due to the lack of data transfer in the milk.
Pregnancy and Breastfeeding
Pregnancy:
Studies in animals have not revealed teratogenic. In the absence of teratogenic effects in animals, a teratogen in humans is not expected. Indeed, to date, the substances responsible for malformations in humans have proven
teratogenic in animals in studies conducted in two species well.
Clinically, there is currently no adequate data to evaluate a possible harmful effect of molsidomine when administered during pregnancy.
Consequently, as a precautionary measure, it is preferable not to use molsidomine during pregnancy.
Breastfeeding:
Breastfeeding is not recommended due to the lack of data transfer in the milk.
Caution
WARNINGS:
- CORVARYL tablets are not suitable for the treatment of angina pectoris.
- Association of molsidomine to sildenafil:
the combination of molsidomine to sildenafil may cause large and sudden drop in blood pressure may be at the origin of faintness, syncope or acute coronary event (see interactions and cons- directions).
- Due to the presence of lactose, this medicine is against-indicated in cases of congenital galactosemia, malabsorption of glucose and galactose or lactase deficiency.
PRECAUTIONS:
- A slight drop in blood pressure is usual under molsidomine. Some caution is necessary in hypotensive patients, particularly in the elderly and / or hypovolemic (acute or chronic salt depletion) and in patients previously
treated with a vasodilator substance.
- A gradual dose is recommended in patients with hepatic insufficiency.
- Devoid of any myocardial depressant effect, molsidomine may be associated with beta-blockers. It has no effect on conduction of the fabric.
- The substitution of nitrates delay is more logical than the association, due to joint action on the preload.
- It is not logical to combine with nitrates molsidomine extended insofar as their mechanism of action is similar action derivatives.
- Pregnancy: Animal studies have not demonstrated a teratogenic effect. In the absence of teratogenic effects in animals, a teratogen in humans is not expected. Indeed, to date, the substances responsible for malformations in
humans have proven teratogenic in animals in studies conducted in two species well. Clinically, there is currently no adequate data to evaluate a possible harmful effect of molsidomine when administered during pregnancy.
Consequently, as a precautionary measure, it is preferable not to use molsidomine during pregnancy.
Interactions with other drugs
Contraindicated:
Sildenafil:
Risk of significant hypotension (synergistic effect) can worsen the condition and cause of myocardial ischemia including an acute coronary event.
Adverse effects
- The usually mild headache and a slight decrease in blood pressure may occur early in treatment. Headaches usually resolve spontaneously within a few days. These effects may be increased by concomitant use of other vasodilators.
A gradual dose allows to reduce the frequency.
- Exceptionally were reported orthostatic hypotension, digestive disorders, dizziness, or itching.
Overdose
Significant hypotension can be controlled by placing the patient supine, head sloping, with elevation of the lower limbs and the need for an intravenous infusion of normal saline or any other means of volume expansion.
Composition
Excipient
Lactose
Crospovidone (E1202)
Magnesium stearate (E572)
Macrogol
Indications
- Preventive treatment of angina attack in all its forms.
- CORVARYL tablets are not suitable for the treatment of angina pectoris.
CORVARYL dose 2 mg scored tablet Box of 30
- Angina of effort (usual dose): 1/2 to 1 tablet 3 times a day, usually the morning meal, lunch and evening (3-6 mg of molsidomine).
- Angor rest angina and severe stress: 1 tablet 4 times a day (8 mg molsidomine).
The choice of dose and administration schedule can be adjusted exactly to the treatment of angina severity and pace of patient activity. In case of spontaneous angina, 4th will be taken preferably at bedtime.
- Preventive treatment of angina attack in all its forms.
- CORVARYL tablets are not suitable for the treatment of angina pectoris.
CORVARYL dose 2 mg scored tablet Box of 30
- Angina of effort (usual dose): 1/2 to 1 tablet 3 times a day, usually the morning meal, lunch and evening (3-6 mg of molsidomine).
- Angor rest angina and severe stress: 1 tablet 4 times a day (8 mg molsidomine).
The choice of dose and administration schedule can be adjusted exactly to the treatment of angina severity and pace of patient activity. In case of spontaneous angina, 4th will be taken preferably at bedtime.
Indications against
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